Examinando por Autor "Berrocal, A."

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Acceso Abierto
Equine infection with Leishmania spp. in Costa Rica: Study of five cases
(Wiley Online Library, 2021-08-02) Salguero, F. J.; García, N.; Domínguez, M.; Moreno, I.; Berrocal, A.; Ortega García, María Victoria; Comunidad de Madrid; Ortega García, M. V. [0000-0002-6948-9591]; Salguero, F. J. [0000-0002-5315-3882]
Background Cutaneous forms of leishmaniosis due to Leishmania braziliensis have been reported in horses in the New World. Domestic animals play a role in the transmission of the disease. In Costa Rica, human cases of L. braziliensis, L. panamensis and L. infantum have been reported. Objectives The present report describes five cases of equine cutaneous leishmaniosis in Costa Rica. The aetiological diagnosis was based on the presence of the parasite within the lesions. Methods Skin biopsies were used to perform histopathological analyses of the lesions. Immunohistochemistry was used to detect the presence of the Leishmania spp. antigens in tissue sections. Laser-capture micro-dissection and quantitative real-time PCR techniques were carried out to detect the pathogen nucleic acid within the microscopic lesions. Results Histopathological analyses showed a granulomatous inflammation within the dermis, with multi-nucleated giant cells, macrophages, lymphocytes and few neutrophils and eosinophils. We detected the parasite by immunohistochemistry, using a rabbit polyclonal antibody raised against Leishmania spp. However, we could not identify Leishmania spp. by quantitative real-time PCR in formalin-fixed paraffin-embedded tissues, using specific primers for the conserved region in the minicircle of the Leishmania DNA kinetoplast. Conclusions Our results emphasise the importance of Leishmania spp. not only as a causative agent of equine cutaneous disease in the New World, but also as a possible emerging pathogen. Leishmaniosis is one of the most prevalent parasitic public health problems worldwide, and equines may have a role in the epidemiology of the disease.
Restringido
Raman Laser Spectrometer (RLS) calibration target design to allow onboard combined science between the RLS and MicrOmega instruments on the ExoMars rover
(Wiley Analytical Science, 2020-01-23) López Reyes, G.; Pilorget, C.; Moral, A.; Manrique, J. A.; Berrocal, A.; Veneranda, M.; Rull, F.; Medina, J.; Hamm, V.; Bibring, J. P.; Rodríguez, J. A.; Pérez Canora, C.; Mateo Martí, Eva; Prieto Ballesteros, O.; Lalla, E.; Vago, J. L.; Sanz de la Rosa, Andrea; Ministerio de Economía y Competitividad (MINECO); Agencia Estatal de Investigación (AEI); López Reyes, G. [0000-0003-1005-1760]; Prieto Ballesteros, O. [0000-0002-2278-1210]; Manrique, J. A. [0000-0002-2053-2819]; Moral, A. G. [0000-0002-6190-8560]; Venerada, M. [0000-0002-7185-2791]; Unidad de Excelencia Científica María de Maeztu Centro de Astrobiología del Instituto Nacional de Técnica Aeroespacial y CSIC, MDM-2017-0737
The ExoMars rover, scheduled to be launched in 2020, will be equipped with a novel and diverse payload. It will also include a drill to collect subsurface samples (from 0‐ to 2‐m depth) and deliver them to the rover analytical laboratory, where it will be possible to perform combined science between instruments. For the first time, the exact same sample target areas will be investigated using complementary analytical methods—infrared spectrometry, Raman spectrometry, and laser desorption mass spectrometry—to establish mineralogical and organic chemistry composition. Fundamental for implementing this cooperative science strategy is the Raman Laser Spectrometer (RLS) calibration target (CT). The RLS CT features a polyethylene terephthalate disk used for RLS calibration and verification of the instrument during the mission. In addition, special patterns have been recorded on the RLS CT disk that the other instruments can detect and employ to determine their relative position. In this manner, the RLS CT ensures the spatial correlation between the three analytical laboratory instruments: MicrOmega, RLS, and MOMA. The RLS CT has been subjected to a series of tests to qualify it for space utilization and to characterize its behavior during the mission. The results from the joint work performed by the RLS and MicrOmega instrument teams confirm the feasibility of the “combined science” approach envisioned for ExoMars rover operations, whose science return is optimized when complementing the RLS and MicrOmega joint analysis with the autonomous RLS operation.
Acceso Abierto
The athena x-ray integral field unit: a consolidated design for the system requirement review of the preliminary definition phase
(Springer Link, 2022-08-30) Barret, Didier; Albouys, Vincent; Herderm Jan-Willem den; Piro, Luigi; Cappi, Massimo; Huovelin, Juhani; Kelley, Richard; Mas-Hesse, J. Miguel; Paltani, Stéphane; Rauw, Gregor; Rozanska, Agata; Fiore, Fabrizio; Bonny, Patrick; Boorman, Peter; Boreux, Charles; Bounab, Ayoub; Cuttaia, Francesco; Gabici, Stefano; Boutelier, Martin; Boyce, Kevin; Molin, Alexeï; Etcheverry, Christophe; Brienza, Daniele; Bruijn, Marcel; Bandler, Simon; Puccio, Elena; Bulgarelli, Andrea; Calarco, Simona; Callanan, Paul; D'Ai, Antonino; Camus, Thierry; Canourgues, Florent; Branduardi-Raymont, Graziella; Cavazzuti, Elisabetta; Gant, Florent; Capobianco, Vito; Cardiel, Nicolás; Castellani, Florent; Cheatom, Oscar; Pascale, Ramon; Chervenak, James; D'anca, Fabio; Gastaldello, Fabio; Ettori, Stefano; Dadina, Mauro; Barbera, Marco; Daniel, Christophe; Peille, Philippe; Gloaguen, Emilie; DeNigris, Natalie; Dercksen, Johannes; DiPirro, Michael; Doumayrou, Eric; Dubbeldam, Luc; Finoguenov, Alexis; Bozzo , Enrico; Dupieux, Michel; Monestes, David; Genolet, Ludovic; Ghizzardi, Simona; Plaa, Jelle de; Alcacera Gil, María Ángeles; Dupourqué, Simon; Giovannini, Elisa; Durkin, Malcom; Grosso, Nicolas; Charles, Ivan; Godet, Olivier; Gómez Elvira, J.; Montinaro, Nicola; González, Manuel; González, Raoul; Gottardi, Luciano; Ardellier, Florence; Granat, Dolorès; Gros, Michel; Pinsard, Frederic; Rioland, Guillaume; Guignard, Nicolas; Hieltjes, Paul; Fioretti, Valentina; Mot, Baptiste; Hurtado, Adolfo Jesus; Costantini, Elisa; Irwin, Kent; Jacquey, Christian; Argan, Andrea; Van der Kuur, Jan; Janiuk, Agnieszka; Jaubert, Jean; Rodriguez, Louis; Jolly, Antoine; Smith, Stephen; Jourdan, Thierry; Julien, Sabine; Geoffray, Hervé; Kedziora, Bartosz; Kaastra, Jelle; Korb, Andrew; Van Leeuwen, Bert-Joost; Dauser, Thomas; Kreykenbohm, Ingo; König, Ole; Langer, Mathieu; Murat, David; Roig, Anton; Laudet, Philippe; Laurent, Philippe; Mazzotta, Pasquale; Laurenza, Monica; Lesrel, Jean; Jacques, Lionel; Bellouard, Elise; Ligori, Sebastiano; Lorenz, Maximilian; Luminari, Alfredo; Nagayoshi, Kenichiro; Decourchelle, Anne; Maffei, Bruno; Colonges, Stéphane; Rollet, Bertrand; Maisonnave, Océane; Marelli, Lorenzo; Massonet, Didier; Maussang, Irwin; Carron, Jérôme; Nazé, Yaël; Roudil, Gilles; Noguès, Loïc; Kirsch, Christian; Pailot, Damien; Chiarello, Fabio; Fossecave, Hervé; Duval, Jean-Marc; Panessa, Francesca; Parodi, Luigi; Petit, Pascal; Piconcelli, Enrico; Adams, Joseph; Pinto, Ciro; Miller, Jon; Rudnicki, Tomasz; Gatti, Flavio; Clerc, Nicolas; Sanisidro, Julien; Encinas Plaza, José Miguel; Sciortino, Luisa; Durand, Jean Louis; Hoogeveen, Ruud; Silva, Vitor; Sordet, Michael; Miniutti, Giovanni; Soto Aguilar, Javier; Spizzi, Pierre; Surace, Christian; Clerc, Laurent; Fernández Sánchez, Miguel; Taralli, Emanuele; Fiorini, Mauro; Goldwurm, Andrea; Hartog, Roland den; Eckert, Dominique; Nicastro, Fabrizio; Jackson, Brian; Svoboda, Jiri; Jonker, Peter; Kilbourne, Caroline; Cobo, Beatriz; Korpela, Seppo; Macculi, Claudio; Mendez, Mariano; Khosropanah, Pourya; Mitsuda, Kazuhisa; Finkbeiner, Fred; Molendi, Silvano; Pajot, François; Eiriz, Valvanera; Pointecouteau, Etienne; Porter, Frederick; Gao, Jian-Rong; Van der Hulst, Paul; Pratt, Gabriel W.; Prêle, Damien; Ravera, Laurent; Sciortino, Salvatore; Martin, Sylvain; Sato, Kosuke; Schaye, Joop; Shinozaki, Keisuke; Skup, Konrad; Ercolani, Eric; Coeur-Joly, Odile; Soucek, Jan; Thibert, Tanguy; Vink, Jacco; Yamaguchi, Hiroya; Kiviranta, Mikko; Webb, Natalie; Perry, James; Chaoul, Laurence; Raulin, Desi; Simionescu, Aurora; Torrejón, José Miguel; Coleiro, Alexis; Acero, Fabio; Beaumont, Sophie; Pradines, Alice; Cucchetti, Edoardo; D'Andrea, Matteo; Le Mer, Isabelle; Reina, M.; Ledot, Aurélien; Eckart, Megan; Ferrando, Philippe; Kammoun, Elias; Lotti, Simone; Fiocchi, Maria Teresa; Mesnager, Jean-Michel; Rigano, Manuela; Van Loon, Dennis; Michalski, Lea; Roelfsema, Peter; Natalucci, Lorenzo; Schwander, Denis; Poyatos Martínez, D.; Ceballos, Maria Teresa; Torrioli, Guido; Ullom, Joel; Medinaceli Villegas, Eduardo; Zuchniak, Monika; Millerioux, Jean-Pierre; Brachet, Frank; Lo Cicero, Ugo; Corcione, Leonardo; Lyautey, Bertrand; Parot, Yann; Prouvé, Thomas; Sakai, Kazuhiro; Doriese, William; Weers, Henk van; Wilms, Joern; Mineo, Teresa; Abdoelkariem, Shariefa; Adam, Thomas; Adami, Christophe; Coriat, Mickael; Aicardi, Corinne; Akamatsu, Hiroki; Merino Alonso, Pablo Eleazar; Ptak, Andy; Amato, Roberta; André, Jérôme; Roncarelli, Mauro; Franssen, Philippe; Angelinelli, Matteo; Añón Cancela, M.; Yamasaki, Noriko; Coynel, Alexandre; Anvar, Shebli; Atienza, R.; Attard, Anthony; Auricchio, Natalia; Puccetti, Simonetta; Duband, Lionel; Balado, A.; Bancel, Florian; Ferrari Barusso, Lorenzo; Frericks, Martin; Bernard, Vivian; Barcons, Xavier; Berrocal, A.; Blin, Sylvie; Audard, Marc; Bonino, Donata; Minervini, Gabriele; Bonnet, François; Jiménez, María; Gonzalo Melchor, Alejandro; VERA TRALLERO, ISABEL; Agencia Estatal de Investigación (AEI); Ministerio de Ciencia e Innovación (MICINN); Centre National D'Etudes Spatiales (CNES); Agenzia Spaziale Italiana (ASI); European Space Agency (ESA)
The Athena X-ray Integral Unit (X-IFU) is the high resolution X-ray spectrometer, studied since 2015 for flying in the mid-30s on the Athena space X-ray Observatory, a versatile observatory designed to address the Hot and Energetic Universe science theme, selected in November 2013 by the Survey Science Committee. Based on a large format array of Transition Edge Sensors (TES), it aims to provide spatially resolved X-ray spectroscopy, with a spectral resolution of 2.5 eV (up to 7 keV) over an hexagonal field of view of 5 arc minutes (equivalent diameter). The X-IFU entered its System Requirement Review (SRR) in June 2022, at about the same time when ESA called for an overall X-IFU redesign (including the X-IFU cryostat and the cooling chain), due to an unanticipated cost overrun of Athena. In this paper, after illustrating the breakthrough capabilities of the X-IFU, we describe the instrument as presented at its SRR, browsing through all the subsystems and associated requirements. We then show the instrument budgets, with a particular emphasis on the anticipated budgets of some of its key performance parameters. Finally we briefly discuss on the ongoing key technology demonstration activities, the calibration and the activities foreseen in the X-IFU Instrument Science Center, and touch on communication and outreach activities, the consortium organisation, and finally on the life cycle assessment of X-IFU aiming at minimising the environmental footprint, associated with the development of the instrument. Thanks to the studies conducted so far on X-IFU, it is expected that along the design-to-cost exercise requested by ESA, the X-IFU will maintain flagship capabilities in spatially resolved high resolution X-ray spectroscopy, enabling most of the original X-IFU related scientific objectives of the Athena mission to be retained.